Our diverse, inclusive team of scientists studies exosome biogenesis, develops exosome-based vaccines and therapeutics, invents synthetic cell signaling pathways, and explores the intracellular trafficking of SARS-CoV-2 spike
Exosomes are small secreted vesicles of ~100 nm in size that play critical roles in human health and disease. We want to understand the molecular mechanisms of exosome cargo protein budding and exosome biogenesis, and their inhibition by endocytosis, plasma membrane-to-lysosome sorting, and lysosome function.
Exosomes are the only bionormal nanovesicle, which makes them an ideal delivery vehicle for vaccines, biologics, and drugs. Our laboratory combines the latest advances in cell and exosome engineering to create exosome-based vaccines and biologics.
Together with the neuroscientist Michael Caterina (JHU SOM), we invent signal-triggered protein trafficking systems, for use as in vivo tools to elucidate mechanisms of signal transduction, and as genetically-encoded therapies to treat chronic pain.
The Gould lab discovered that SARS-CoV-2 Spike is a lysosomal protein, and that the earliest mutation in spike, D614G, arose to correct a defect in spike trafficking to lysosomes. Our lab seeks to understand the mechanisms of spike sorting to lysosomes and how this contributes to the formation and egress of SARS-CoV-2, and its endolysosomal route of infection.
We seek motivated scientists interested in answering fundamental questions in cell biology, and translating that knowledge into new vaccines and therapeutics. Candidates with a background in biochemistry, cell biology, genetics, or bioengineering are encouraged to apply.
We welcome rotation students from the BCMB graduate program and the Biological Chemistry graduate program, of which Steve is Director. To discuss potential rotation projects, or for inquiries about the Graduate Program in Biological Chemistry Ph.D. program, send an email to Steve.
Send an email with a statement of interest and CV to Steve. We are particularly interested in post-doctoral candidates with expertise in cell biology, biochemistry, synthetic biology/bioengineering, and pre-clinical studies of vaccines or drugs. Candidates must have a strong record of independent research.
We also welcome undergraduates who are hungry for a substantial research experience (15+ hours per week during school year or full time in summer). Please email Steve with a CV and statement of interest. Ideally, we expect a long-term commitment to a research project, typically 2-3 academic years.